Perhaps. A variance request may be appropriate, and may be submitted to the municipal Zoning Hearing Board (ZHB) when a zoning regulation inflicts unnecessary hardship. The ZHB may grant the variance if the ZHB finds all of the following apply: there are unique physical conditions that prevent the property from being developed according to zoning Ordinance, the variance is necessary for reasonable use of the property, the hardship was not self-created, the character of the neighborhood will not be changed, the use of adjacent property and the public welfare will not be adversely affected, and the variance permits the minimum relief from the regulation.
A special exception is probably not appropriate and/or does not apply in this instance, unless the use of the building is listed specifically as a special exception in the zoning ordinance. A special exception involves a specific use which is permitted in a particular zoning district, subject to certain standards and conditions. Applications for special exceptions are decided by the ZHB.